Cephalosporin

Cephalosporine

Cephalosporine is a one kind of beta-lactum antibiotic derived from Acromonium fungus which was known as cephalosporium.

Cephalosporine is indicated in prophylaxis and infection caused by bacteria.

First generation cephalosporine was only active against gram positive bacteria. But the successive generation of cephalosporine is active against gram positive and gram nrgative else.

Mechanism of Action

Mode of action of Cephalosporine is just like other beta-lactum antibiotic, but difference is that it is less susceptible to beta-lactamase enzyme.

Cephalosporine antibiotic disrupt the synthesis of peptidoglycan layer of cell wall and therefore disrupt the cell wall synthesis in bacteria. Causes bacterial death.

Example

Cefexime- 3rd generation cephalosporine

Ceftriaxone- 3rd generation cephalosporine